Life Under Pandemic Drives Eye Injuries

UCSF Ophthalmology residents are on the front line at Zuckerberg San Francisco General Hospital and Trauma Center, where the evolving COVID pandemic and attendant social upheaval present new health challenges. During these tough times, residents are working to preserve and save sight for the city’s most vulnerable people.

Close-up of a child's eye reflecting trees.Children Injured by Sanitizer

Resident Lawrence Chan, MD, reports incidents of young children experiencing eye injuries from splashed or squirted hand sanitizers. Available everywhere to reduce COVID transmission, the alcohol base of these cleaners is toxic to the eye. Irritation, painful burns, or even ulcers on the cornea can result from direct contact.

Fortunately, corneal tissue can regenerate from superficial burns, allowing the eye to regain clear sight. Dr. Chan recommends keeping dispensers away from children’s eye level and watching out for automatic dispensers in public places. Adults, especially health care workers who must use sanitizer very frequently, must also be careful to avoid touching the eyes after sanitizing their hands.

 

Hand receiving liquid from a pump bottle.Anti-Asian Attacks

Hate-fueled attacks on Asian Americans have escalated nationally during the pandemic. The eye is particularly vulnerable to damage. This year, resident Lauren Hennein, MD, along with Dr. Chan, have treated Asian Americans struck in the face or fired on with a gun.

“We must all voice support for our Asian American neighbors,” says Alejandra de Alba Campomanes, MD, Department Vice Chair for Diversity, Equity, and Inclusion. “This institution believes that the best defense against hate, intolerance, and ignorance is care, compassion, and empathy.”

More Than Meets the Eye

Colorful neurons with cell nuclei in a microscopy image.
Microscopic image of ganglion cells in a mouse retina, a valuable research tool.

Early Detection of Cognitive Diseases

Principal investigator (PI), Xin Duan, PhD, and his team, which includes both co-PI Erik Ullian, PhD, and Kongyan Wu, PhD, seek to address a vital problem in neurodegeneration: how can nerve-damaging diseases be identified earlier to prevent more extensive damage?

Conceptually, Dr. Duan’s team aims to use the retina to establish a way to identify early signs of disease. Instead of simply focusing on the cell biology of degenerating neurons, this team of leading-edge investigators propose to investigate the problem by taking a larger view of the neural circuits within the eye and its component parts.

“There is increasing evidence that the visual system is involved in most neurogenerative diseases and thus could provide a novel early diagnostic inroad to common diseases such as Alzheimer’s and frontotemporal degeneration (FTD)/amyotrophic lateral sclerosis (ALS),” Dr. Ullian contributed. “Furthermore, we can map circuit function with unprecedented precision in the visual system, so it will undoubtedly give us greater insight into specific mechanisms of neuronal and circuit dysfunction in these diseases.”

Visual circuits – the neural networks that give us sight – offer great advantages for analyzing general neural circuits as they are highly accessible with well-characterized synaptic contacts and functional properties. Moreover, the retina and the visual pathways have recently been shown to be easily observable clinically.

Dr. Duan reasons that neural circuit studies represent a major advancement in the analysis of neurodegeneration-related changes.

Dr. Duan’s studies in visual circuits will shed light on other neural circuits across the central nervous system and may lead to early detection of Alzheimer’s disease in patients. They are investigating potential synergies in neurodegenerative disease research, including both glaucoma and Alzheimer’s. Dr. Duan and his team aim to establish a way to detect disease onset, evaluate its progression, and establish a platform to discover dysfunctional neural circuits – with the ultimate goal of preventing neurodegeneration and restoring circuit functions.

Fading Senses Turned Her into a Fighter

Although nearly both blind and deaf, Rebecca Alexander is an inspiration to us all. She is an author, psychotherapist, group fitness instructor, disability rights advocate, and extreme athlete.

Woman smiling with arms crossed outdoors.
Rebecca Alexander was born and raised in the San Francisco Bay Area. She currently resides in New York City where she has a thriving private psychotherapy practice. Her brother is NBC Chief White House correspondent Peter Alexander.

A patient of UCSF ophthalmologist, Jacque Duncan, MD, Rebecca was born with Usher syndrome type 3A, a rare genetic disorder which has caused progressive loss of both her sight and hearing since she was a teenager. Despite these unfathomable challenges, Rebecca maintains her drive for life, rising above and beyond every challenge she faces.

In 1996, young Rebecca was selected to be an Olympic torchbearer in the nationwide relay prior to the Atlanta Games because of her ability to face adversity with grace and courage. Since then, her extraordinary accomplishments have included summiting Mt. Kilimanjaro, participating in the 600-mile San Francisco to Los Angeles AIDS Lifecycle ride, swimming from Alcatraz to shore in the San Francisco Bay for That Man May See’s Swim for Sight, skydiving, bungee jumping, and regularly competing in events for extreme athletes.

Sharing her story to help others face their own challenges, Rebecca presented for TEDx Cape May What’s the Story? She has been widely featured on such shows as The Today Show, NBC Nightly News, Morning Joe, The Dr. Oz Show, ABC News, NBC News, and PBS Radio. She has also been featured in The New York Times, The Boston Globe, The Boston Herald, The New York Post, USA Today, Huffington Post, Fitness, Shape, Women’s Health, Marie Claire, and Cosmopolitan.

Her book, Not Fade Away: A Memoir of Senses Lost and Found, tells the 42-year-old author’s story of courage and motivation from starting to lose sight and hearing as a child, to a shattering fall from a window at 18, to her triumph over these physical, psychological, and philosophical obstacles. Her inspiring story is now the subject of a forthcoming Netflix feature film from Annapurna Pictures, produced by John Krasinski and David O. Russell.

Over the years, Rebecca has won a number of awards, including a Helen Keller Achievement Award from the American Foundation for the Blind, the Foundation Fighting Blindness Hope and Spirit Award, and the Future Visions Foundation’s Luminary Award to name a few.

An Eye for the Arts

Illustration of a woman with red hair and glasses, against a colorful background.
Digital illustration by Sean Choate, depicting Ellie’s experience.

Ellie Stokes faced a uniquely challenging time during the COVID-19 pandemic lockdowns, but found artistic creativity to be the perfect outlet.

In May 2020, Ellie was diagnosed by her doctor, neuro–ophthalmologist Nailyn Rasool, MD, with a rare form of double vision due to an artery compressing her sixth cranial nerve.

One treatment for her double vision was using prism glasses. These glasses are specialized, refracting light before it enters the eyes so that the light falls in the same spot on both retinas, creating a single image.

Since being prescribed prism glasses, Ellie has done very well. “I just love Dr. Rasool,” she said. “She’s been so wonderful and the whole staff at UCSF are incredibly supportive and welcoming.”

Ellie, a songwriter, has been working on an album that reflects on her experience and, as part of her inspiration, commissioned her friend Sean Choate to create the above illustration. “That’s what it felt like, two eyes under the glasses lens,” Ellie said.

Ellie is looking forward to releasing her album, possibly by the end of this year.

Pediatric Pals

Recently, while young Mackenzie Fredeen was waiting for treatment, she met another toddler, Akira Pierre, going through a very similar experience.

We first met Mackenzie last year, when her parents generously requested charitable gifts to That Man May See for vision research at University of California, San Francisco in lieu of first birthday presents for their daughter. Mackenzie was diagnosed with retinoblastoma (eye cancer) at just three-and-a-half-months old.

Two young girls smiling, playing on a slide.
Akira (left) and Mackenzie (right): pals and patients.

Fortunately, she found compassionate care at UCSF through specialist Armin Afshar, MD, MBA and his colleague, nurse Leanne Parsons, MS. Pediatric ophthalmology at UCSF strives to make small patients, courageously facing monumental challenges, feel like family while they are in treatment. “The combination of leading-edge expertise and humanitarian patient care for these child warriors is what makes Dr. Afshar’s team so successful. We are forever grateful,” according to Jordanna Howard, Mackenzie’s mother.

As only children can, Mackenzie and Akira made an instant connection. At the time, Akira was bravely undergoing treatment in ocular oncology – and the two girls immediately bonded, holding hands and playing together. Mackenzie and Akira have both since been deemed cancer-free. Their parents are grateful to Dr. Afshar for his unmatched care. Mackenzie and Akira found joy and hope in one another, and inspire all of us here at That Man May See.

A Dream Realized

Inside UCSF Ophthalmology’s New Home

 

Making It Official

After nearly a decade – from the initial plans to bring the Department of Ophthalmology and the Francis I. Proctor Foundation together on the Mission Bay Campus to the recent completion of the new core facility – the Wayne and Gladys Valley Center for Vision is making an impact.

The Center, which, along with research, teaching, surgical, and administration facilites, houses the world-class Koret and Proctor Foundation clinics, began to see patients in the new Mission Bay location in October 2020. Due to COVID-19, stringent safety guidelines were implemented and the official virtual Opening Celebration was delayed until February 18, 2021.

“Our new center provides the platform for continually advancing ophthalmology, further transforming the field, empowering UCSF leaders, researchers, clinicians, residents, fellows, and students to tackle enormous challenges ahead through innovation and collaboration that Mission Bay colleagues inspire,” said Kathleen Rydar, President Emerita of That Man May See.

UCSF Chancellor Sam Hawgood, MBBS, acknowledged the Wayne and Gladys Valley Foundation “for its generosity and foresight in the creation of this building, which will help to advance the groundbreaking work of all those who call it home. Your tireless commitment to improving vision treatments and care for all those in our communities is nothing short of inspiring.”

Dr. Hawgood went on to recognize Department Chair Stephen McLeod, MD, for “his remarkable leadership of the Department of Ophthalmology, as well as all of the faculty and staff, whose work every single day impacts the lives of our patients and their families. They embody our commitment, redefining possible with their passion and dedication to improving vision and eye health for all. […] I would like to thank the many leaders on our faculty, staff, and the UCSF Capital Projects team for their important role in the planning, design, and construction of this building and the dedicated team at That Man May See for their partnership and commitment to this project. Each of you has helped to make possible this transformational facility which holds tremendous promise for discovery and for healing countless patients in our care.”

Additional recognition goes to the contributions of UCSF Events Director Mary Hoffman; UCSF Events Manager Liz Purdy; Vice President of the UCSF Foundation and UCSF Vice Chancellor of University Development and Alumni Relations Jennifer Arnett; and the Board of Directors of That Man May See.

 

Wayne and Gladys Valley Center for Vision
The Wayne and Gladys Valley Center for Vision; an exam room; the Joan and David Traitel Lounge; the Tom and Yvonne Mazzocco Surgical Laboratory.

Under One Roof

For many years, UCSF eye care programs were in multiple locations throughout San Francisco. Now research scientists and physicians across a wide spectrum of vision- and eye-related disciplines have been brought together at UCSF’s Mission Bay campus with many more to follow. This will facilitate coordinated patient care and extend the boundaries of scientific discovery.

“The Wayne and Gladys Valley Center for Vision supports instrumental collaboration between some of the most brilliant minds combating visual disease today and delivers on our commitment to transforming lives,” said Dr. McLeod.

The new home for UCSF Ophthalmology owes its creation to the commitment and generosity of patients, physicians, and donors, and will bring hope to those impacted by vision complications around the world.

“The transcendent beauty of true philanthropy,” said University of California President Michael Drake, MD, “is that your contributions will be a gift to people far and wide for generations to come – people you will never know, but whose lives will be better because of you.”

“The cutting-edge research that will be accomplished here and the care our experts provide will impact the quality of life for countless individuals of all ages for years to come…” – Deborah Chesky, That Man May See President

The Patient Experience

Access to renowned ophthalmologists, surgeons, optometrists, and scientists has been expanded to facilitate more of the community through 80 patient care rooms and over 45,000 square feet of clinic space. The Wayne and Gladys Valley Center for Vision has been designed with visually impaired visitors’ needs in mind, providing a welcoming and inclusive experience for all who come through its doors. Function, equity, and comfort were all carefully incorporated by the architects.

Set to welcome more than 160,000 patient visits a year, the Wayne and Gladys Valley Center will offer eye care ranging from routine to complex and multidisciplinary specialty care services. This includes advanced cataract and corneal surgery, complex glaucoma, ocular inflammatory disease, orbital disease and eye tumors, challenging retinal disorders, and neuro-ophthalmological conditions facilitated by the latest therapeutic and diagnostic equipment.

“The cutting-edge research that will be accomplished here and the care our experts provide will impact the quality of life for countless individuals of all ages for years to come,” said Mrs. Chesky. “Our faculty members and alumni are truly poised to save sight and to save lives.”

On February 18, 2021, so many helped us celebrate the opening of The Center. Thank you.

This special virtual event featured remarks by University of California President Michael Drake, MD; UCSF Chancellor and Arthur and Toni Rembe Rock Distinguished Professor Sam Hawgood, MBBS; Dean of the School of Medicine and Vice Chancellor of Medical Affairs Talmadge E. King, Jr., MD; Chair of UCSF Ophthalmology Department and Theresa M. and Wayne M. Caygill, MD, Distinguished Professor and Chair Stephen D. McLeod, MD; That Man May See President Deborah Chesky, President Emerita Kathleen Rydar, and Chair of the Board John de Benedetti. It also included a tour of the Valley Center, led by Dr. McLeod.

Special guests at the live event which followed the virtual opening celebration, included Dr. Michael Drake, Chancellor Sam Hawgood, Dr. Talmadge King, Michael Desler, Dr. Stephen McLeod, Ruth Hoffman, Ron Conway, Dr. David and Victoria Chang, Don and Judy McCubbin, John de Benedetti and Nina Srejovic, Tom and Johanna Baruch, Lily Huang, John Stock, John Rohal, Pat and Phil Jelley; Drs. Tom and Chihori Lietman; Kathleen Rydar; and Deborah Chesky.

View the Opening Celebration online: https://www.thatmanmaysee.org/valley-opening

Schedule your next appointment at the Wayne and Gladys Valley Center for Vision today. Call 415.353.2800 Monday-Friday, 8 a.m. – 5 p.m.

New UC President: An Old Friend of UCSF

 

A man in a suit with glasses standing in front of a window.

DID YOU KNOW?

Dr. Drake has been on the faculty of UCSF’s Department of Ophthalmology for over 20 years.

 

Michael V. Drake, MD, has been selected as the 21st president of the University of California (UC) world-renowned system of ten campuses, five medical centers, three nationally-affiliated labs, more than 280,000 students and 230,000 faculty and staff. He is the first person of color to serve as UC President in the system’s 152-year history.

With a long and distinguished career in higher education, Dr. Drake most recently served as president of Ohio State University (OSU) since 2014. Prior to his six years at OSU, his entire academic career has been at UC, including as chancellor of UC Irvine from 2005 to 2014 and as the systemwide vice president for Health Affairs from 2000 to 2005.

His appointment is especially exciting as Dr. Drake is a longtime UCSF colleague. He received his medical degree is from UCSF, did his residency and fellowship in ophthalmology here, and subsequently spent more than two decades on the faculty of the UCSF School of Medicine, including as the Steven P. Shearing Professor of Ophthalmology. He was also Vice Chair of the Department of Ophthalmology and Senior Associate Dean for Admissions and Extramural Academic Programs in the School of Medicine.

Under his leadership as Chancellor, Dr. Drake greatly enhanced UC Irvine’s reputation as a premier university. UC Irvine rose to join the Top 10 Public Universities in U.S. News & World Report’s annual list and was ranked by Times Higher Education as the No. 1 university in the US under 50 years old. During his tenure, the fouryear graduation rate increased by more than 18 percent, while undergraduate enrollment and diversity significantly increased. In addition, Dr. Drake oversaw the establishment of new schools of law and education as well as programs in public health.

He has published numerous scientific articles and co-authored six textbooks. Dr. Drake is a member of several national scientific and scholarly societies including the American Academy of Arts and Sciences, the Institute of Medicine, and the National Academies of Science. He has received several awards for teaching, public service, mentoring, and research.

Dr. Drake and his wife, Brenda, have two grown sons and four grandchildren.