A woman smiling while sitting indoors.

Felice Dunn, PhD

Associate Professor

 

Mechanisms of the anatomical and functional changes to the retina following photoreceptor loss

The Dunn lab aims to advance understanding of retinal synaptogenesis and signal pathway regulation that could enable future therapies directed against loss of primary sensory neurons. Our lab currently has projects directed to accomplish the following goals:

1. To determine how specific connections are established at the visual system’s first synapse
2. To determine how rod vs. cone signals are independently regulated within the retinal circuit.
3. Identify the extent and sites of compensation within the retinal circuitry following partial photoreceptor loss.
4. Determine the contributions of partial stimulation, adaptation, and homeostatic plasticity to retinal responses following partial photoreceptor loss.
5. To determine the degree of input loss that induces constructive vs. destructive structural and functional changes within the retinal circuit.

 

To Learn More:

https://profiles.ucsf.edu/felice.dunn
https://dunnlab.ucsf.edu/

 

Research Areas:

Retina or Retinal Diseases, Visual System Development
 
 
Learn more about UCSF Ophthalmology faculty research.

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A man in a white coat with a blue shirt and striped tie.

Ari Green, MD

Professor

 

Understanding multiple sclerosis (MS) and related disorders

Division Chief of one of the largest Neuroimmunology research groups in the world, Dr. Green is dedicated to understanding multiple sclerosis and related disorders. The Green lab is particularly interested in developing means of harnessing glial biology to help repair damage to the central nervous system and in measuring this repair using vision-based metrics with an enhanced understanding of the visual system. His team has developed and optimized methods for performing visual evoked potentials and electroretinography in rodents and tools for determining the cellular and molecular basis of the signals detected. Also, he led the clinical translational team dedicated to the development of small molecules capable of remyelination and independently led the first successful clinical trial for remyelination in the setting of chronic injury in MS. He has mentored 19 postdoctoral fellows, 4 visiting fellows/faculty, 31 medical students and 10 specialists to careers in Medicine or lab research. He committed to mentoring residents and medical students with an interest in Neurology, Neuro-immunology, and Neuro-ophthalmology. He is helping to mentor junior faculty with an interest in careers in translational science and works closely with partners and colleagues from the basic sciences to cultivate a mentorship program. The Green lab will provide opportunities for Scholars with an interest in translational vision sciences, visual system injury and repair, and clinical trials work.

 

To Learn More:

https://profiles.ucsf.edu/ari.green
https://greenlab.ucsf.edu/
 

Research Areas:

Neuro-Ophthalmology, Multiple Sclerosis, Visual System Function in Adults
 
Learn more about UCSF Ophthalmology faculty research.

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