Matilda Chan, MD, PhD

Associate Professor


Molecular Mechanisms Underlying Corneal Injury, Inflammation, and Repair

Dr. Chan, Associate Professor of Ophthalmology, is a cornea clinician-scientist interested in understanding the molecular mechanisms underlying corneal injury, inflammation, and repair. Dr. Chan’s R01 is focused on the role of matrix metalloproteinases (MMPs) in modulating various aspects of corneal repair after injury including inflammation, neovascularization, and fibrosis. She is also studying the epigenetic and genetic alterations underlying Fuch’s endothelial cell dystrophy (FECD), specifically the role of DNA methylation as a mechanism for silencing genes during disease pathogenesis. In collaboration with Jason Gestwicki (UCSF), her group is using high throughput screening to identify compounds for the treatment of FECD. Dr. Chan has mentored undergraduates, medical students, postdoctoral fellows, residents, and clinical fellows. The Chan lab would provide opportunities for Scholars interested in the role of extracellular matrix in ocular disease, epigenetics, and translational vision science.


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Research Areas:

Cornea, Matrix Metalloproteinases, Infectious Diseases
Learn more about UCSF Ophthalmology faculty research.