UCSF Department of Ophthalmology

Tyson Kim, MD, PhD

Principle Investigator

I’m a clinician-scientist trained in bioengineering, vascular biology, and ophthalmology. My research centers on studying cellular-level dynamics and physiology in intact tissues with an emphasis on developmental and vascular diseases of the eye. We create advanced optical and computational methods, and merge these with genetic approaches to understand disease in new and elegant ways. I love innovative research, mentoring, and am motivated by the patients I’m privileged to care for. Outside of work I enjoy hiking, wrenching on cars, and spending time with loved ones.

Guiying Hong, MD, MS

Research Specialist

I graduated from medical school in China, Received graduate degree in Japan. I then moved to the US. My research interest is develop of a comprehensive understanding of mechanisms of vascular development and dysgenesis, with study specialized models of disease and with advanced intravital imaging and quantitative analysis. I study vascular development and blood flow deeper in living tissues by using multi-photon. When not working I enjoy music, cooking, hiking, and movies.

Wenhao (Henk) Shang, PhD

Postdoctoral Fellow

I earned my BSc in Biotechnology from Huazhong University of Science & Technology, and my Ph.D. from Peking University in Biomedical Engineering. My interest in science derived from a desire to combine advanced imaging techniques with single/spatial transcriptomics for the multi-scale study of the bio-system, ideally finding treatment for human disease, so I joined Dr. Tyson Kim’s lab. For my project, I use a two-photon/three-photon microscope and spatial transcriptomics in the age-related macular degeneration (AMD) mouse model. My focus is on the quantification of chorioretinal anastomoses and identifying the molecular mechanism of neovasculature, then exploring the possible treatment for it. When not working I enjoy spending time with my family, playing badminton, and walking my dogs.

Ryan Morton

Research Specialist

I earned my BA in Statistics and minored in German Studies at Cornell University. There I was part of the Schaffer-Nishimura lab, where I worked on a multi-photon ablation approach to treating focal epilepsy, used machine learning methodologies to study animal behavior, collected and analyzed electrophysiology data, and investigated the role of sharp wave ripples in a mouse model of Alzhiemer’s Disease. Having developed a strong foundation and interest in optical and surgical techniques, I joined the Kim Lab at UC San Francisco where I am now using multi-photon imaging to study vascular dysgenesis in a variety of eye diseases like Retinitis Pigmentosa and Age-Related Macular Degeneration. When I’m not working, I enjoy hiking and occasionally go backpacking in national parks like Yosemite.

Liangbo (Linus) Shen, MD

Resident

I am an ophthalmology resident at the University of California, San Francisco, with a background in biomedical and optical engineering, imaging analysis, and retinal diseases. I received my Bachelor of Engineering degree summa cum laude from Duke University, where I worked on intraoperative optical coherence tomography and co-invented a stereoscopic heads-up display system for ophthalmic surgeries under the guidance of Drs. Joseph Izatt and Cynthia Toth. I then earned my medical degree cum laude from Yale School of Medicine. In medical school, I co-developed a novel statistical method to investigate the long-term natural history of age-related macular degeneration and inherited retinal degeneration based on fundus imaging under the mentorship of Dr. Lucian Del Priore, MD, PhD. I also studied the development of retinal nerve fiber in preterm infants using optical coherence tomography in Dr. Cynthia Toth’s lab. As an aspiring physician-scientist, I am passionate about translating novel imaging techniques to the clinical setting and understanding the process of ocular diseases.

Evan Chen, MD

Resident

I am currently an ophthalmology resident at UCSF. I previously earned my BS in biomedical engineering degree at Yale College and my medical degree at Yale Medical School. I am passionate about big data analysis and my previous work has focused on improving healthcare delivery using insights from claims databases. I also am specifically interested in leveraging ophthalmic imaging to optimize treatment approaches.

Arman Mosenia, MD

Resident

I am a 4th-year medical student at UCSF. I have a background in materials engineering, bio-design, and data science, and am currently interested in research at the intersection of devices and medical big data. As an aspiring ophthalmologist, I am driven to develop clinical interventions and tools that improve quality and accessibility of ophthalmic care.

Malinda Bell

Lab Administrator

I’m proud to work for UCSF and meet a diverse group of students and doctors who are dedicated to the field of Ophthalmology. I enjoy working with the Tyson Kim Lab because the environment and lab members are innovative and engaging. My other interests include psychology, photography, and visiting museums.

Favorite Quote: “No masterpiece was ever created by a lazy artist.” -Salvador Dali

Tom Gentry

P30 Core Manager, Computer/IT Support

Prior to joining Tyson Kim’s lab at UCSF, I worked as a computer vision engineer applying deep learning to identify agricultural pathogens from hyperspectral images. I completed my BS in Business Administration from the University of Utah. As a core member of Tyson’s lab, my specific aim is to apply state of the art, computer vision algorithms to develop novel methods of quantitative inquiry in the field of hemodynamics. When I get the opportunity, I enjoy traveling home to Hawaii, scuba diving and spending time with friends.

Yien-Ming Kuo

P30 Core Manager, Morphology

I received my undergraduate degree from Glasgow University, Scotland, my PhD from Imperial Collage, London, and my Postdoc from UC Berkeley on genetics of fly salivary gland development.

I joined UCSF to generate and characterize mouse models of human metabolic disorders and Parkinson’s disease. In the Ophthalmology Department, I oversee the Morphology module of the P30 Vision Core and provide services and expertise in histology, confocal and bright field microscopy as well as visual functional testing and ocular imaging.