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Frank Brodie, MD, MBA

Assistant Professor

 

Technology for Peripheral Retinal Imaging

I have been collaborating extensively with Duke Bioengineering in developing novel technologies to obtain far peripheral OCT imaging of the retina in an effort to detect retinal breaks early and without the challenging and uncomfortable scleral depressed exam. Additionally we have used intraoperative peripheral OCT to visualize subtle pathologic changes not previously noted on clinical exam.

 
 

To Learn More:

https://profiles.ucsf.edu/frank.brodie

Research Areas:

Mobile Health, Retina or Retinal Diseases, OCT, Optical Coherenece Tomography, Peripheral Retina Imaging
 
Learn more about UCSF Ophthalmology faculty research.

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Yvonne Ou, MD

Associate Professor

 

Cellular and Synaptic Mechanisms of Glaucomatous Neurodegeneration

The Ou laboratory studies the cellular and synaptic mechanisms of glaucomatous neurodegeneration. We are particularly interested in understanding the earliest steps of inner retina circuit disassembly in response to injury. Our research program combines imaging and analysis of specific cell and synaptic labels in the retina, rodent models of experimental glaucoma, novel genetic tools in which specific cell types are labeled, and the tools of molecular/cell biology and physiology to address a series of questions that, unanswered, have prevented progress in the field: 1) What are the early steps of compartmentalized neurodegeneration of the ganglion cell in glaucoma? 2) Are there specific ganglion cell types that are more susceptible to intraocular pressure (IOP) elevation? 3) Are there specific inner retinal circuits that are more susceptible to IOP elevation? As a clinician-scientist, I am motivated to advance our field not only by answering these fundamental questions, but also by translating the knowledge gained into improvements in diagnostic and treatment modalities in glaucoma. For example, a detailed understanding of the earliest structural and functional changes that occur in glaucoma will allow us to design treatments that can rescue RGCs, perhaps the most susceptible RGCs, before irreversible cell death occurs.

 

To Learn More:

https://profiles.ucsf.edu/yvonne.ou
https://ophthalmology.ucsf.edu/oulab/

 

Research Areas:

Glaucoma, Mobile Health, Visual System Function in Adults
 
 
Learn more about UCSF Ophthalmology faculty research.

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