David Hwang, MD

Professor

 

Cornea, Ocular Infectious Disease and Surgical Techniques

A native of Illinois, USA, David G. Hwang, MD, FACS, joined the full-time faculty at the University of California, San Francisco, where he is currently Professor and Vice Chair and holds the Pearl T. Kimura and Samuel J. Kimura MD Endowed Chair in Ophthalmology. He serves as Director of the Cornea Service, Director of the Refractive Surgery Service, and Associate of the Francis I. Proctor Foundation for Research in Ophthalmology at UCSF. Clinical research interests: development of new surgical techniques in corneal, refractive, and cataract surgery; clinical trials in cornea and ocular infectious disease. Scientific research interests: cellular transplantation and gene therapy for corneal endothelial disease; ocular infectious disease, including epidemiology and mechanisms of antimicrobial resistance in ophthalmology

 

To Learn More:

https://profiles.ucsf.edu/david.hwang


 

Research Areas:

Cornea, Gene Therapy, Infectious Diseases
 
Learn more about UCSF Ophthalmology faculty research.

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Deepak A. Lamba, M.B.B.S., Ph.D.

Associate Professor

 

Retinal Repair Following Inherited and Age-Associated Degeneration

Dr. Lamba leads an NIH-funded laboratory focused on using human stem cells for retinal repair following inherited and age-associated degeneration. He utilizes stem cell technologies to generate disease-in-a-dish models or for cell replacement. The key research interests include (1) exploring the potential and challenges in retinal cell replacement therapies esp. the role of the tissue microenvironment and (2) developing stem-cell based model systems to understand various human retinal degenerations and identifying new therapeutic avenues including genome editing technologies like CRISPR. Dr. Lamba is a natural collaborator with clinician-scientists and since joining the Department in 2018 he has established collaborations with Drs. Jacque Duncan and Tony Moore. Dr. Lamba has mentored numerous pre- and postdoctorates and is also a member of the education committee. His group will provide opportunities for Scholars interested in harnessing the power of novel stem cell technologies to clinical problems especially retinal degenerations.

 

To Learn More:

https://profiles.ucsf.edu/deepak.lamba
http://lambalab.ucsf.edu
https://ophthalmology.ucsf.edu/lambalab/

 

Research Areas:

Gene Therapy, Retinitis Pigmentosa or Retinal Degenerations, Stem Cell Research, Leber Congenital Amaurosis, Retinal Development, Pluripotent stem cells, Cell replacement
 
 
Learn more about UCSF Ophthalmology faculty research.

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Bruce R. Conklin, MD

Professor

 

Therapeutic Approaches to Genetic Disease

Dr. Conklin uses induced pluripotent stem (iPS) cells, both from patients and engineered to have particular mutations to model human disease. His lab is developing new genome engineering methods in human iPS cells to identify therapeutic targets in cardiac, motor neuron and retinal diseases. Trainees will utilize CRISRP technology for therapeutic genome editing, then test the effect of genome editing in diseases modeled in iPS cells. The combination of human iPS cells and genome editing provide unprecedented opportunities to explore new areas of biology and discover new therapies for disease. Dr. Conklin has mentored many graduate students and postdoctoral fellows in the lab. He has on-going collaborations with Dr. Shen that has led to a publication in Nat Genetics 2019 and Dr. Lakkaraju studying water transport across the retinal pigment epithelial (RPE), as a functional measure of gene correction in Best’s disease. Scholars interested in the use of state-of-the-art therapeutic genome editing strategies and stem cell biology will find opportunities in Dr. Conklin’s lab.

 

To Learn More:

https://profiles.ucsf.edu/bruce.conklin
https://labs.gladstone.org/conklin/
https://ucsfhealthcardiology.ucsf.edu/people/bruce-conklin
 

Research Areas:

Gene Research, Gene Therapy, Stem Cell Research
 
Learn more about UCSF Ophthalmology faculty research.

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