Jacque Duncan, MD



High resolution retinal imaging in inherited retinal degeneration

Dr. Duncan, Professor of Ophthalmology, leads an NIH-funded translational vision science laboratory focused on adaptive optics scanning laser ophthalmoscopy (AOSLO) imaging of human photoreceptors to discover mechanisms of cone death in inherited retinal degenerations. In addition, Dr. Duncan’s group is studying changes in cone structure and function during disease progression and testing the efficacy of treatments that aim to slow progression. Along with her collaborator Austin Roorda, PhD (UC Berkeley), they reported the first studies of cone structure during disease progression and in response to an experimental treatment. Dr. Duncan is also Co-PI with Joseph Carroll, PhD (Medical College of Wisconsin) on an NEI-funded Audacious Goals Initiatives proposal that will develop cone-dominant retinal disease models as a resource for translational vision research. Dr. Duncan’s group will characterize photoreceptor structure and function in patients with cone-rod dystrophy. In addition, Dr. Duncan is the Chair of the Foundation Fighting Blindness Consortium Executive Committee. She is the study chair of a natural history study examining the rate of retinal degeneration due to mutations in the USH2a gene (the RUSH2A study). She also serves as principal investigator on a number of clinical trials of treatments and natural history of disease progression in inherited retinal degenerations including retinitis pigmentosa and Usher syndrome.


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Research Areas:

Retina or Retinal Diseases, Retinitis Pigmentosa or Retinal Degenerations, Macular Degeneration, Adaptive optics, Retinal imaging
Learn more about UCSF Ophthalmology faculty research.