Douglas Gould, PhD



Studying the biological functions of the extracellular matrix and its role in human disease

Our broad mission is to understand the biological functions of a specialized extracellular matrix structure called the Basement Membrane.

Our primary focus is a multi-system disorder that is caused by mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and COL4A2.

Our goal is to understand the tissue-specific molecular mechanisms that underlie this syndrome and develop mechanism-based therapies that can prevent, reduce or delay disease in patients.

The Gould lab uses translational genetics to study the role that extracellular matrix proteins play in a multisystem connective tissue disorder caused by mutations in type IV collagens. Individuals with mutations in type IV collagen alpha 1 (COL4A1) or alpha 2 (COL4A2) often have a complex syndrome presenting with cerebrovascular, ocular, renal and muscular manifestations. Approximately one-third of these individuals have developmental defects of the eye leading to impaired vision or early onset glaucoma. The Gould lab uses genetic models to understand the molecular mechanisms underlying pathology in each organ that might represent therapeutic targets to prevent, reduce, or delay disease. Dr. Gould is the Director and Vice Chair for research and is dedicated trainee advocate and mentor with a commitment to inclusivity. The Gould lab provides research opportunities for Scholars interested in state-of-the-art genetic approaches, extracellular matrix biology, cell biology, physiology, biochemistry and advanced imaging.


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Research Areas:

Glaucoma, Retina or Retinal Diseases, Gene Research
Learn more about UCSF Ophthalmology faculty research.