Selected Publications



A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci. Choquet H, Paylakhi S, Kneeland SC, Thai KK, Hoffmann TJ, Yin J, Kvale MN, Banda Y, Tolman NG, Williams PA, Schaefer C, Melles RB, Risch N, John SWM, Nair KS, Jorgenson E. Nat Commun. 2018 Jun 11;9(1):2278.

Müller glia-derived PRSS56 is required to sustain ocular axial growth and prevent refractive error. Paylakhi S, Labelle-Dumais C, Tolman NG, Sellarole MA, Seymens Y, Saunders J, Lakosha H, deVries WN, Orr AC, Topilko P, John SW, Nair KS. PLoS Genet. 2018 Mar 12;14(3):e1007244.

A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure. Choquet H, Thai KK, Yin J, Hoffmann TJ, Kvale MN, Banda Y, Schaefer C, Risch N, Nair KS, Melles R, Jorgenson E. Nat Commun. 2017 Dec 13;8(1):2108.

YBR/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17. Nair KS, Cosma M, Raghupathy N, Sellarole MA, Tolman NG, de Vries W, Smith RS, John SW. Dis Model Mech. 2016 Aug 1; 9(8):863-71. PMID: 27483353.

Determining immune components necessary for progression of pigment dispersing disease to glaucoma in DBA/2J mice. Nair KS, Barbay J, Smith RS, Masli S, John SW BMC Genet. 2014;15, 42

ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma. Nongpiur ME, Khor CC, Jia H, Cornes BK, Chen LJ, Qiao C, Nair KS, Cheng C-Y et al. PLOS Genet. 2014;10(3), e1004089.

Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalamia in humans and mice. Nair KS*, Hmani-Aifa M*, Ali Z, Kearney AL, Salem SB, Macalinao DG, Cosma IM, Bouassida W, Hakim B, Benzina Z, Soto I, Söderkvist P, Howell GR, Smith R, Ayadi H, John SWM. 2011. Nat Genet. 43:579-584.

Mutations in the RNA Granule Component TDRD7 Cause Cataract and Glaucoma. Lachke SA, Alkuraya FS, Kneeland SC, Ohn T, Aboukhalil A, Howell GR, Saadi I, Cavallesco R,  Yue Y, Tsai ACH, Nair KS, Cosma MI, Smith RS, Hodges E, AlFadhli SM, Al-Hajeri A, Shamseldin HE,  Behbehani AM, Hannon GJ, Bulyk ML, Drack AV, Anderson PJ, John SWM, Maas RL. Science. 2011. 33:1571-1576. PMID: 21436445

GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. Anderson MG*, Nair KS*, Amonoo LA, Mehalow A, Trantow C, Masli S, John SWM. 2008. BMC Genet. 2008 9(30). PMID: 18402690

Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions. Nair KS*, Hanson SM*, Gurevich, EV, Vishnivetskiy SA, Mendez A, Kennedy M, Hurley J, Chen J., Gurevich VV, Slepak VZ. 2005. Neuron. 46:555-567. PMID: 15944125